O le faʻataʻitaʻiga na faʻaalia ai le maualuga-televave o quaternary ammonium disinfectants e fai ma togafitiga mo le tele o siama, e aofia ai coronavirus: o nei gaioiga e ala i le faʻaaogaina o le lipid coating puipuia lea e faʻaogaina ai siama e pei o le SARS-CoV-2.Quaternary ammonium compounds o lo'o fautuaina lautele e tape ai siama ma e silia ma le 350 oloa i luga ole EPA's List N: Disinfectants mo le fa'aogaina e faasaga i le SARS-CoV-2 (Supplementary Material. The disinfectant concentrations and contact times (faʻafesoʻotaʻi ma le tele o siama) mo le tele o faʻamaʻi pipisi. vaila'au i luga o le lisi EPA ua lipotia ma > 140 e mafai ona tape le siama i ni nai minute (18).
O lenei faʻamatalaga na taʻitaʻia ai i matou i se suʻesuʻega sili atu mo quaternary ammonium compounds ma gaioiga e tetee atu ai i coronavirus ma mafai ona iloagofie o vailaʻau ua uma ona faʻataʻitaʻiina i totonu o le falemaʻi ma mafai ona faʻaaogaina e fai ma togafitiga mo le COVID-19.O se tasi o vailaʻau faʻamaʻi ua faʻaalia e faʻaleagaina i siama (Mataʻi Faʻaopoopo) ma faʻaaogaina lautele i oloa tausi tagata o le cetylpyridinium chloride.Ole mea lea e maua tele ile fufulu gutu ma o lo'o lisiina e le FDA o le Generally Regarded as Safe (GRAS) ma o loʻo faʻaaogaina foʻi e fai ma vailaʻau faʻamaʻi mo aano o manufasi ma moa (e oʻo atu i le 1%).Cetylpyridinium chloride ua faʻaaogaina i le tele o suʻesuʻega faʻataʻitaʻi, e aofia ai o se togafitiga e faasaga i faʻamaʻi pipisi e faʻamaonia ai lona faʻaogaina o se antiviral.O le Cetylpyridinium e ono fa'aosoina ai le fa'agataina o le siama e ala i le fa'aumatiaina o le capsid fa'apea fo'i ma ana gaioiga lysosomotropic, lea, e pei ona talanoaina i luga, e masani ai mo fa'apotopotoga ammonium quaternary.O le mea lea e tulaʻi mai ai le fesili pe o nisi o vailaʻau o loʻo faʻaalia i le antiviral activity e faasaga i le SARS-CoV-2 in vitro e amio tutusa, e mafai ona latou faʻaumatia le virus capsid faʻapea foʻi ma le faʻaputuina i le lysosome poʻo le endosomes ma iu ai ina poloka le viral entry.O suʻesuʻega faʻaopoopo faʻasalalau ua fautua mai ai e mafai ona faʻaitiitia lenei aʻafiaga e ala i le faʻaogaina o le inhibitors Cathepsin-L.
Cetylpyridinium chloride(CPC)
Quaternary ammonium fa'atasi ma le fa'aogaina o le coronavirus
| Molecule | Gaioiga Antiviral | Fa'ainisinia | Ua faamaonia e le FDA | Fa'aoga |
| Ammonium Chloride | Murine coronavirus, hepatitis C, | Lysosomotropic | Ioe | Fa'aoga eseese e aofia ai le metabolic acidosis. |
| Cetylpyridinium chloride | Influenza, hepatitis B, poliovirus 1 | Fa'atatau i le capsid ma e lysosomotropic | Ioe, GRAS | Antiseptic, mouthwash, tale lozenges, oloa mo le tausiga o le tagata lava ia, vailaau fa'amama ma isi. |
Taimi meli: Au-03-2021