Olivetol, e taʻua foi o le 5-pentylresorcinol, o se mea faʻapitoa faʻapitoa na maua le gauai tele i tausaga talu ai mo ana mea tau vailaau ma fale gaosi oloa.O se mole muamua mo le biosynthesis o mea eseese, e aofia ai cannabinoids o loʻo maua muamua i le laau cannabis.Malamalama i le biosynthesis oolivetole taua tele le iloa o lona gafatia ma su'esu'e ona fa'aoga eseese.
O le biosynthesis oOlivetolamata i le condensation o lua molelaula o malonyl-CoA, maua mai le acetyl-CoA, e ala i le gaioiga o se enzyme e taʻua polyketide synthase.O lenei fa'aupuga fa'afefe e ta'ita'i atu ai i le fa'atūina o se mea fa'alotoifale e ta'ua o le geranyl pyrophosphate, o se mea e masani ai i le biosynthesis o mea fa'anatura eseese, e aofia ai terpenes.
Geranyl pyrophosphate ona liua lea i le olive acid e ala i se faasologa o gaioiga enzymatic.O le laasaga muamua e aofia ai le fesiitaiga o se vaega o le isoprenyl mai le geranyl pyrophosphate i se mole mole hexanoyl-CoA, ma fausia ai se tuufaatasiga e taʻua o le hexanoyl-CoA olive acid cyclase.O lenei gaioiga fa'ata'amilomilo e fa'atupuina e se enzyme e ta'ua o le hexanoyl-CoA:olivelate cyclase.
Le isi laasaga i totonuolivetolbiosynthesis e aofia ai le liua o le hexanoyl-CoA olivetate cyclase i se faiga malosi e taʻua o le tetraketide intermediate.E maua lenei mea e ala i le fa'asologa o gaioiga fa'aenzymatic fa'apipi'iina e enzymes e pei ole chalcone synthase, stilbene synthase, ma le resveratrol synthase.O nei gaioiga e taʻitaʻia ai le faʻavaeina o le tetraketide intermediates, ona liua lea i le olivetol e ala i le gaioiga o le polyketide reductase.
Fa'atasiolivetolua faʻapipiʻiina, e mafai ona sili atu ona liua i ni mea faʻapitoa, e aofia ai cannabinoids, e ala i le gaioiga o enzymes e pei o le cannabidiolic acid synthase ma le delta-9-tetrahydrocannabinolic acid synthase.O nei enzymes e fa'atupuina le fa'aputuga oolivetolfaʻatasi ai ma geranyl pyrophosphate poʻo isi molelaʻau muamua e fausia ai ni cannabinoids eseese.
I le faaopoopo atu i lana matafaioi i le biosynthesis cannabinoid,olivetolua maua o lo'o iai ni mea fa'ama'i fa'ama'i ma mea fa'asao.O suʻesuʻega ua faʻaalia ai lena meaolivetole mafai ona taofia le tuputupu aʻe o le tele o fungal pathogens, ma avea ai ma sui tauva mo le atinaʻeina o vailaʻau faʻamaʻi.E le gata i lea,olivetolua fa'aalia e iai le malosi o le fa'a'ave'esea o fa'ama'i e fa'asaga i fa'ama'i sa'oloto, o molela'au fa'ato'aga e mafai ona fa'aleagaina ai sela ma a'a.O lenei meatotino antioxidant oolivetolo lo'o fa'ailoa mai ai lona fa'aogaina i le atina'eina o vaila'au fa'afoma'i mo le togafitia o fa'ama'i fa'ama'i fa'ama'i fa'ama'i.
I se aotelega, o le biosynthesis oolivetole aofia ai le condensation o malonyl-CoA molelaula, sosoo ai ma se faasologa o tali enzymatic, e mafua ai le fausia oolivetol.O lenei tuufaatasiga e avea o se mole muamua i le biosynthesis o cannabinoids faapea foi ma isi oloa masani.Malamalama i le biosynthetic ala oOlivetole taua tele i le atinaʻeina o ana faʻaoga talafeagai i vailaʻau ma fale gaosi oloa.Su'esu'ega atili ile biosynthesis oolivetolma ona mea e maua mai e mafai ona taitai atu ai i le mauaina o vailaau fou fou ma fesoasoani i le atinaeina o fualaau fou.
Taimi meli: Nov-13-2023